Publikationen

Publikationen (peer-viewed)

  1. Schwabe, K, Ewe, A, Kohn, C, Loth, T, Aigner, A, Hacker, MC, Schulz-Siegmund, M. Sustained delivery of siRNA poly- and lipopolyplexes from porous macromer-crosslinked gelatin gels. Int. J. Pharm. 2017 (accepted).
  2. Hendrikx S, Kuzmenka, D, Köferstein, R, Flath T, Uhlig, H, Enke, D, Schulze P, Hacker MC, Schulz-Siegmund M. Effects of curing and organic content on bioactivity and mechanical properties of hybrid sol-gel glass scaffolds made by indirect rapid prototyping. Journal of Sol-Gel Science and Technology. 2017 (accepted).
  3. Kascholke C, Loth T, Kohn-Polster C, Möller S, Bellstedt P, Schulz-Siegmund M, Schnabelrauch M, Hacker MC. Dual-Functional Hydrazide-Reactive and Anhydride-Containing Oligomeric Hydrogel Building Blocks. Biomacromolecules. 2017;18(3):683-694. doi: 10.1021/acs.biomac.6b01355.
  4. Müller BM, Loth R, Hoffmeister PG, Zühl F, Kalbitzer L, Hacker MC, Schulz-Siegmund M. Surface modification of copolymerized films from three-armed biodegradable macromers - an analytical platform for modified tissue engineering scaffolds. Acta Biomater. 2017;51:148-160. doi: 10.1016/j.actbio.2017.01.018.
  5. Sülflow K, Schneider M, Loth T, Kascholke C, Schulz-Siegmund M, Hacker MC, Simon JC, Savkovic V. Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel. J Biomed Mater Res A. 2016;104(12):3115-3126. doi: 10.1002/jbm.a.35832.
  6. Schulze J, Hendrikx S, Schulz-Siegmund M, Aigner A. Microparticulate poly(vinyl alcohol) hydrogel formulations for embedding and controlled release of polyethylenimine (PEI)-based nanoparticles. Acta Biomater. 2016;45:210-222. doi: 10.1016/j.actbio.2016.08.056.
  7. Kohn C, Klemens JM, Kascholke C, Murthy NC, Kohn J, Brandenburger M, Hacker MC. Dual-component collagenous peptide/reactive oligomer hydrogels as potential nerve guidance materials – from characterization to functionalization. Biomater Sci. 2016;4(11):1605-1621. doi: 10.1039/c6bm00397d.
  8. Sedaghati B, Jahroomishirazi R, Starke A, C. Hacker M, Schulz-Siegmund M. Rat osteosarcoma cells as a therapeutic target model for osteoregeneration via sclerostin knockdown, Cells Tissues Organs 2016;201(5):366-379. doi: 10.1159/000444634.
  9. Picke AK, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC. Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function. Biomaterials. 2016;96:11-23. doi: 10.1016/j.biomaterials.2016.04.013.
  10. Hendrikx S, Kascholke C, Flath T, Schumann D, Gressenbuch M, Schulze P, Hacker MC, Schulz-Siegmund M. Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration - effects of organic crosslinker valence, content and molecular weight on mechanical properties. Acta Biomater. 2016;35:318-329. doi: 10.1016/j.actbio.2016.02.038.
  11. Hacker MC, Nawaz HA. Multi-functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine. Int J Mol Sci. 2015;16(11):27677-27706. doi: 10.3390/ijms161126056.
  12. Roßteuscher-Carl K, Fricke S, Hacker MC, Schulz-Siegmund M. Influence of in line monitored fluid bed granulation process parameters on the stability of Ethinylestradiol, Int J Pharm. 2015;496(2):751-758. doi: 10.1016/j.ijpharm.2015.10.074.
  13. Loth R, Loth T, Schwabe K, Bernhardt R, Schulz-Siegmund M, Hacker MC. Highly adjustable biomaterial networks from three-armed biodegradable macromers. Acta Biomater. 2015;26:82-96. doi: 10.1016/j.actbio.2015.08.008.
  14. Savkovic V, Flämig F, Schneider M, Sülflow K, Loth T, Lohrenz A, Hacker MC, Schulz-Siegmund M, Simon J-C. Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle, J Biomed Mater Res A. 2016;104(1):26-36. doi: 10.1002/jbm.a.35536.
  15. van der Smissen A, Hoffmeister PG, Friedrich N, Watarai A, Hacker MC, Schulz-Siegmund M, Anderegg U. Artificial extracellular matrices support cell growth and matrix synthesis of human dermal fibroblasts in macroporous 3D scaffolds. J Tissue Eng Regen Med. 2015. doi: 10.1002/term.2037.
  16. Jahroomishirazi R, Bader A, Ebert S, Schmidt C, Sedaghati B, Schulz-Siegmund M, Zscharnack M. Isolation and Characterization of CD271+ Stem Cells Derived from Sheep Dermal Skin. Cells Tissues Organs. 2014;200(2):141-152. doi: 10.1159/000381534.
  17. Schröck K, Lutz J, Mändl S, Hacker MC, Kamprad M, Schulz-Siegmund M. Co(II)-mediated effects of plain and PIII-modified cobalt-chromium alloys on the osteogenic differentiation of human mesenchymal stem cells, J Orthop Res. 2015;33(3):325-333. doi: 10.1002/jor.22765.
  18. Schwarz S, Huss R, Schulz-Siegmund M, Vogel B, Brandau S, Lang S, Rotter N. Bone-marrow derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion. International Journal of Oral Science. 2014;6(3):154-161. doi: 10.1038/ijos.2014.23.
  19. Loth T, Hötzel R, Kascholke C, Anderegg U, Schulz-Siegmund M, Hacker MC. Gelatin-based biomaterial engineering with anhydride-containing oligomeric cross-linkers. Biomacromolecules 2014;15:2104-2118. doi: 10.1021/bm500241y.
  20. Steinhagen M, Hoffmeister PG, Nordsieck K, Hötzel R, Baumann L, Hacker M, Schulz-Siegmund M, Beck-Sickinger A. Matrix Metalloproteinase 9 (MMP-9) Mediated Release of MMP-9 Resistant Stromal Cell-Derived Factor 1α (SDF-1α) from Surface Modified Polymer Films, Applied Materials and Interphaces 6. 2014;5891-5899. doi: 10.1021/am500794q.
  21. Roßteuscher-Carl K, Fricke S, Hacker MC, Schulz-Siegmund M. In-line monitoring of particle size in a fluid bed granulator: Investigations concerning positioning and configuration of the sensor. Int J Pharm. 2014;466(1-2):31-37. doi: 10.1016/j.ijpharm.2014.02.044.
  22. Rotter N, Schwarz S, Huss R, Schulz-Siegmund M, Vogel B, Branda, S, Lang S. Bone-marrow derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion. International Journal of Oral Science. 2014;6:154–161. doi: 10.1038/ijos.2014.23.
  23. Schneider H, Sedaghati B, Naumann A, Hacker MC, Schulz-Siegmund M. Gene silencing of chordin improves BMP-2 effects on osteogenic differentiation of human adipose tissue-derived stromal cells. Tissue Eng Part A. 2014;20(1-2):335-345. doi: 10.1089/ten.TEA.2012.0563.
  24. Wei R, Oeser T, Barth M, Weigl N, Lübs A, Schulz-Siegmund M, Hacker MC, Zimmermann W. Turbidimetric analysis of the enzymatic hydrolysis of polyethylene terephthalate nanoparticles. J. Mol. Catal. B: Enzym. 2014;103:72-78. doi: 10.1016/j.molcatb.2013.08.010.
  25. Schröck K, Schneider H, Lutz J, Hacker MC, Mändl S, Kamprad M, Schulz-Siegmund M. Cytocompatibility of nitrogen plasma ion immersed medical cobalt-chromium alloys. J Biomed Mater Res A. 2014;102(6):1744-1754. doi: 10.1002/jbm.a.34842.
  26. Mai M, Hempel U, Hacker MC, Dieter P. Effects of HyStem (TM)-HP Hydrogel Elasticity on Osteogenic Differentiation of Human Mesenchymal Stromal Cells. Cell Mol Bioeng. 2014;7:155-164. doi: 10.1007/s12195-013-0314-7.
  27. Loth T, Hennig R, Kascholke C, Hötzel R, Hacker MC. Reactive and stimuli-responsive maleic anhydride containing macromers – multi-functional cross-linkers and building blocks for hydrogel fabrication. React Funct Polym. 2013;73:1480-1492. doi: 10.1016/j.reactfunctpolym.2013.08.002.
  28. Hoyer J, Schatzschneider U, Schulz-Siegmund M, Neundorf I. Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery. Beilstein J Org Chem. 2012;8:1788-97. doi: 10.3762/bjoc.8.204.
  29. Penk A, Förster Y, Scheidt HA, Nimptsch A, Hacker MC, Schulz-Siegmund M, Ahnert P, Schiller J, Rammelt S, Huster D. The pore size of PLGA bone implants determines the de novo formation of bone tissue in tibial head defects in rats. 2013;70(4):925-935. doi: 10.1002/mrm.24541.
  30. Hassert R, Hoffmeister PG, Pagel M, Hacker M, Schulz-Siegmund M, Beck-Sickinger AG. On-Resin Synthesis of an Acylated and Fluorescence-Labeled Cyclic Integrin Ligand for Modification of Poly(lactic-co-glycolic acid). Chemistry & Biodiversity. 2012;9:2648-2658. doi: 10.1002/cbdv.201200290.
  31. Pavlica S, Schmitmeier S, Gloeckner P, Piscioneri A, Peinemann F, Krohn K, Siegmund-Schulz M, Laera S, Favia P, Bartolo L de, Bader A. Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes. J Tissue Eng Regen Med. 2012;6:486-496. doi: 10.1002/term.453.
  32. Weber F, Böhme J, Scheidt HA, Gründer W, Rammelt S, Hacker, M, Schulz-Siegmund M, Huster D. 31P and 13C Solid-State NMR Spectroscopy to Study Collagen Synthesis and Biomineralization in Polymer-Based Bone Implants. NMR in Biomedicine. 2012;25:464-475. doi: 10.1002/nbm.1649.
  33. Ambrosch K, Mannhardt M, Loth T, Bernhard R, Schulz-Siegmund M, Hacker, MC. Open Porous Microscaffolds for Cellular and Tissue Engineering by Lipid Templating. Acta Biomaterialia. 2012;8:1303-1315. doi: 10.1016/j.actbio.2011.11.020.
  34. Böhme J, Anderegg U, Nimptsch A, Nimptsch K, Hacker M, Schulz-Siegmund M, Huster D, Schiller J. De novo biosynthesis of GAG in the extracellular matrix of skin studied by MALDI MS, Analytical Biochemistry. 2012;421:791-93. doi: 10.1016/j.ab.2011.11.002.
  35. Pavlica S, Piscioneri A, Peinemann F, Keller M, Milosevic J, Staeudte A, Heilmann A, Schulz-Siegmund M, Laera S, Favia P, De Bartolo L, Bader A. Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials. 2009;30:6514-6521. doi: 10.1016/j.biomaterials.2009.08.024.
  36. De la RB, Nowak C, Sanchez E, Hernandez A, Schulz-Siegmund M, Pec MK, Delgado A, Evora C. VEGF-controlled release within a bone defect from alginate/chitosan/PLA-H scaffolds. Eur J Pharm Biopharm. 2009;73:50-58. doi: 10.1016/j.ejpb.2009.04.014.
  37. Nemec K, Germ E, Schulz-Siegmund M, Ortner A. The effect of nimodipine, fentanyl and remifentanil intravenous products on the stability of propofol emulsions. Pharmazie. 2009;64:94-97. doi: 10.1691/ph.2008.8161.
  38. Lorenz K, Sicker M, Schmelzer E, Rupf T, Salvetter J. Schulz-Siegmund M, Bader A. Multilineage Differentiation Potential of Human Dermal Skin Derived Fibroblasts, Exp Dermatol. 2008;17:925-932. doi: 10.1111/j.1600-0625.2008.00724.x.
  39. Hacker M, Ringhofer M, Neubauer M, Vogel T, Appel B, Young S, Mikos AG, Blunk T, Göpferich A, Schulz MB. Solid Lipid Templating: Solid lipid Templating of macroporous tissue engineering scaffolds, Biomaterials. 2007;28:3497-3507. doi: 10.1016/j.biomaterials.2007.04.018.
  40. Ahmed N, Vogel B, Rohde E, Strunk D, Grifka J, Schulz MB, Grassel S. CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells, Int.J Mol.Med. 2006;18:233-240.
  41. Neubauer M, Hacker M, Bauer-Kreisel P, Weiser B, Fischbach C, Schulz MB, Goepferich A, Blunk T. Adipose Tissue Engineering Based on Mesenchymal Stem Cells and Basic Fibroblast Growth Factor in vitro. Tissue Eng. 2005;11(11/12):1840-1851. doi: 10.1089/ten.2005.11.1840.
  42. Lieb E, Vogel T, Milz S, Dauner M, Schulz MB. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. II: Osteoblastic differentiation. Tissue Eng. 2004;10:1414-1425. doi: 10.1089/ten.2004.10.1414.
  43. Lieb E, Milz S, Vogel T, Hacker M, Dauner M, Schulz MB. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. I. Culture conditions and tissue formation. Tissue Eng. 2004;10:1399-1413. doi: 10.1089/ten.2004.10.1399.
  44. Lieb E, Hacker M, Tessmar J, Kunz-Schughart LA, Fiedler J, Dahmen C, Hersel U, Kessler H, Schulz MB, Gopferich A. Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides. Biomaterials. 2005;26:2333-2341. doi: 10.1016/j.biomaterials.2004.07.010.
  45. Neubauer M, Fischbach C, Bauer-Kreisel P, Lieb E, Hacker M, Tessmar J, Schulz MB, Goepferich A, Blunk T. Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells. FEBS Lett. 2004;577:277-283. doi: 10.1016/j.febslet.2004.10.020.
  46. Tessmar J, Kellner K, Schulz MB, Blunk T, Gopferich A. Toward the Development of Biomimetic Polymers by Protein Immobilization: PEGylation of Insulin as a Model Reaction. Tissue Eng. 2004;10: 441-453. doi: 10.1089/107632704323061807.
  47. Kellner K, Tessmar J, Milz S, Angele P, Nerlich M, Schulz MB, Blunk T, Gopferich A. PEGylation Does Not Impair Insulin Efficacy in Three-Dimensional Cartilage Culture: An Investigation toward Biomimetic Polymers. Tissue Eng. 2004;10:429-440. doi: 10.1089/107632704323061799.
  48. Hacker M, Tessmar J, Neubauer M, Blaimer A, Blunk T, Göpferich A, Schulz MB. Towards biomimetic scaffolds - Anhydrous scaffold fabrication from biodegradable amine reactive diblock copolymers, Biomaterials. 2003;24(24):4459-4473. doi: 10.1016/S0142-9612(03)00346-6.
  49. Lieb E, Tessmar J, Hacker M, Fischbach C, Rose D, Blunk T, Mikos AG, Goepferich A, Schulz MB. Poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether Diblock Copolymers Control Adhesion and Osteoblastic Differentiation of Marrow Stromal Cells, Tissue Eng. 2003;9(1):69-82. doi: 10.1089/107632703762687555.
  50. Kellner K, Liebsch G, Klimant I, Wolfbeis OS, Blunk T, Schulz MB, Gopferich A. Determination of oxygen gradients in engineered tissue using a fluorescent sensor, Biotechnol. Bioeng. 2002;80:73-83. doi: 10.1002/bit.10352.
  51. Kellner K, Lang K, Papadimitriou A, Leser U, Milz S, Schulz MB, Blunk T, Gopferich A. Effects of hedgehog proteins on tissue engineering of cartilage in vitro, Tissue Eng. 2002;8:561-572. doi: 10.1089/107632702760240481.
  52. Kellner K, Schulz MB, Gopferich A, Blunk T. Insulin in tissue engineering of cartilage: a potential model system for growth factor application, J. Drug Target. 2001;9:439-448. doi: 10.3109/10611860108998778.
  53. Schulz M, Daniels R. Hydroxypropylmethylcellulose (HPMC) as emulsifier for submicron emulsions - Influence of molecular weight and substitution type on the droplet size after high pressure homogenisation, Eur. J. Pharm. Biopharm. 2000;49:231-236. doi: 10.1016/S0939-6411(00)00069-2.

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Weitere Publikationen und Buchkapitel

  1. Sedaghati B, Hoyer J, Aigner A, Hacker MC, Schulz-Siegmund M. Controlled Release Technologies for RNAi Strategies in Regenerative Medicine In: Gustav Steinhoff (Ed): Regenerative Medicine - from Protocol to Patient. 2016.
  2. Flath T, Hacker M, Schulz-Siegmund M, Schulze P. Bioaktive Implantate im FDM-Verfahren. In: 3-D & Industrie, Mitteldeutsche Forum Rapid Technologien, DESOTRON. 2014.
  3. Schulz-Siegmund M, Hötzel R, Hoffmeister PG, Hacker MC. Synthesis, Processing and Characterization of Ceramic Biomaterials for Biomedical Applications, Chapter 3. In: Balaji Sitharaman (Ed), Nanobiomaterials Handbook, CRC Press. 2011.
  4. Hacker M, Ambrosch K, Schulz-Siegmund M. Macroporous Polymer Scaffolds Through Leaching Processes. In: Macroporous Polymers: Production, Properties and Biotechnological/Biomedical Application Ashok Kumar, Igor Yu Galeaev (Eds). CRC Press. 2009.
  5. Schuessele A, Volk B, Mayr H, Blunk T, Schulz MB, Goepferich A. Surface modification of hydroxyapatite ceramics to modulate cell adhesion and improve tissue generation, In: Proceedings of the 9th conference on ceramics, cells and tissues: chemistry and microstructure, the. Ed. Ravaglioli A, Krajewski A, Forli. 2005.
  6. Schulz M, Blunk T, Göpferich A. Lebende Gewebe aus dem Reagenzglas - Wie sich Knochen, Knorpel und andere Gewebe in vitro erzeugen lassen, Blick in die Wissenschaft. 1999.
  7. Schulz M, Blunk T, Göpferich A. Bioabbaubare Polymere: Tür zu Arzneiformen und künstlichen lebenden Geweben, Pharmazeutische Zeitung. 1999.
  8. Blunk T, Schulz M, Göpferich A. Herstellung künstlicher Gewebe unter Einsatz von Biopolymeren und Applikationsformen zur kontrollierten Freigabe. In: Kayser O, Müller RH (Eds.), Pharmazeutische Biotechnologie, Wissenschaftliche Verlagsgesellschaft. 2000.

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Patente

  1. Deutsche Patentanmeldung Nr. 10 2014 224 654.7 „Makroporöse, bioabbaubare organisch-vernetzte Silikat-Hybridmaterialien zur Implantation“ (angemeldet).
  2. Savkovic V, Dieckmann C, Simon JC, Schulz-Siegmund M, Hacker M. Method for deriving melanocytes from the hair follicle outer root sheath and preparation for grafting WO2013060899 A3 (Juni 20, 2013).
  3. Göpferich A, Tessmar J, Schulz M, Blunk T, Mikos A. Biodegradable Block Copolymers with Modifiable Surface. WO 20070299227 (Dezember 27, 2007).
  4. Lauer K, Lang K, Papadimitriou A, Reiff U, Schulz M, Blunk T, Goepferich A. Methods and Reagents for Tissue Engineering in vitro, WO 20060246041, (November 2, 2006).
letzte Änderung: 24.05.2017