Forschung

Biomaterials for regenerative purposesapplications

Polymers and macromers

In order to create substitution for lost bone tissue, we process our materials into 3D-pore-interconnected scaffolds. Our biomaterials contain biodegradable poly- or oligoester sequences or peptides that can be hydrolyzed enzymatically or simply by aqueous incubation. Cross-polymerization of macromeric building blocks is another key feature of our materials. 2-, 3- and 4-armed synthesized macromers can be cross-polymerized by radical polymerization to form films and scaffolds. Scaffolds are processed via different methods, among them additive manufacturing and solid lipid templating. Surface modification of films and scaffolds is another subject we focus on.

We also develop hydrogel-forming macromers with a special focus on anhydride-containing oligomers that are used for the formulation of ECM-mimetic hydrogels with natural macromolecules, such as gelatinous peptides and processed into gels, particles and tubes.

Currently supported by German Research Council (DFG SFB/Transregio 67 A1) and Saxon Ministry for Science and Arts (Grand Grant no: 4-7531.60/64/18), BMWI-ZIM (16KN056824 VDI)

Publications:

Müller BM, Loth R, Hoffmeister PG, Zühl F, Kalbitzer L, Hacker MC, Schulz-Siegmund M. Surface modification of copolymerized films from three-armed biodegradable macromers - an analytical platform for modified tissue engineering scaffolds. Acta Biomater. 2017;51:148-160. doi: 10.1016/j.actbio.2017.01.018.

Loth R, Loth T, Schwabe K, Bernhardt R, Schulz-Siegmund M, Hacker MC. Highly adjustable biomaterial networks from three-armed biodegradable macromers. Acta Biomater. 2015;26:82-96. doi: 10.1016/j.actbio.2015.08.008.

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Bioglass

Bioactive glasses are highly interesting materials in the context of bone regeneration and bone substitution. They possess bioactivity, which means that they actively support the formation of hydroxyapatite on their surface and support the integration in the surrounding bone tissue. The major drawback is their brittleness. One of our interests is to overcome this problem and develop new hybrid materials that contain three- or four-armed organic crosslinkers. We established a new method to process our hybrids to marcroporous, sterilizable and mechanically stable scaffolds via an indirect rapid prototyping technique.

Cooperation partners: Prof. Peter Fritz Schulze, HTWK Leipzig

Publication:

Hendrikx S, Kascholke C, Flath T, Schumann D, Gressenbuch M, Schulze P, Hacker MC, Schulz-Siegmund M. Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration - effects of organic crosslinker valence, content and molecular weight on mechanical properties. Acta Biomater. 2016;35:318-329. doi: 10.1016/j.actbio.2016.02.038.

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Ceramics

In cooperation with InnoTere GmbH, we investigate calcium phosphate ceramics as scaffold materials for controlled release of drugs with a focus on nucleic acids.

This project is currently supported by the SAB and the Saxonian Ministry of science and arts (Grand Grant no: 4-7531.60/64/18).

Cooperation partners: Prof. Peter Fritz Schulze, HTWK Leipzig and Prof. Achim Aigner, Rudolf Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig

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Controlled release of siRNA

SiRNA and miRNA are able to silence proteins on the mRNA level. These nucleic acids have great potential to treat otherwise undrugable targets and diseases. The main problems of these potential drugs are 1. low permeability due to high negative charge and high molecular weight and 2. low stability against degradation. Complexation via polycations, such as polyethyleneimine (PEI) and its derivatives and cationic lipids helps to overcome these problems. Integration and controlled release of these nanocomplexes from implants and scaffolds for tissue regeneration is one of our aims.

We currently focus on bone regeneration. In order to support bone regeneration and osteogenic differentiation, we are interested in silencing wnt and BMP-2 antagonists in human derived mesenchymal stem cells and cell lines.

Currently supported by the Saxon Ministry for Science and Arts (Grand Grant no: 4-7531.60/64/18)

letzte Änderung: 23.08.2017