Research

The section of Pharmaceutical/Medicinal Chemistry is specialised in structure-activity-related syntheses and the analysis of pharmaceutical ingredients. Syntheses of heterocyclic ring systems are of particular importance.

Group JProf. Dr. Hansen

• Rational design and diversity-oriented synthesis of isoform-selective histone deacetylase (HDAC) inhibitors
• Development of parasite-selective antiplasmodial HDAC inhibitors
• Design and synthesis multi-target drugs
• Development of novel peptidomimetic α-helix mimetics to modulate protein-protein interactions

Group Dr. Burda-Daghish

• Green redox chemistry employing enzyme reaction
• Biocascade reaction and bioprocess development
• Development of new methods for the detection of protein-binding fragments via dynamic fragment ligation

Group Prof. Dr. Briel

• Syntheses of annulated heterocycles as inhibitors of PDE 2A and 10A
• Syntheses of quinazoline derivatives as Adenosine A₃ Receptor Antagonists
• Development of tricyclic PDE2A-Inhibitors and their use as PET-Radiotracer

• Synthesis of thieno[2,3-c]pyrazoles having antiulcerative activity
• Synthesis of heterocyclic thioethers with potentially immunomodulating effects
• Synthesis of - linked via a heteroatom - heterobicycles and hetero-carbocycles with inhibitory effect on the cellular uptake of triiodothyronine
• Synthesis and synthetic potential of monocyclic 6-imino-1,3-thiazines
• Synthesis of 2-amino-5-(het)-arylthiophenes and links from cimetidine type as glutamate antagonists
• Synthesis of pyrazolopyrimidines as adenosine A_2A antagonists
• Synthesis and conversion reactions of thieno[2,3-d] pyrimidines and thieno [2,3-d]-[1,3]oxazines as inhibitors of the human leukocyte elastase
• Studies on the synthesis of benzylated and monoglucosidic flavonoids as potential inhibitors of protein kinases
• Synthesis and structure-activity optimization of diaryl thiazolo[5,4-c]pyrimidines as adenosine A_3A antagonists
• Investigations on subtype-specific GABA_A ligands
• Development and evaluation of novel high-affinity fluorescence probes and small molecule inhibitors für sialyltransferases