Research

The section of Pharmaceutical/Medicinal Chemistry is specialised in structure-activity-related syntheses and the analysis of pharmaceutical ingredients. Syntheses of heterocyclic ring systems are of particular importance.
The actual research is focused on
- Rational design and diversity-oriented synthesis of isoform-selective histone deacetylase (HDAC) inhibitors
- Development of parasite-selective antiplasmodial HDAC inhibitors
- Design and synthesis multi-target drugs
- Development of novel peptidomimetic α-helix mimetics to modulate protein-protein interactions
- Green redox chemistry employing enzyme reaction
- Biocascade reaction and bioprocess development
- Development of new methods for the detection of protein-binding fragments via dynamic fragment ligation
- Syntheses of annulated heterocycles as inhibitors of PDE 2A and 10A
- Syntheses of quinazoline derivatives as Adenosine A3 Receptor Antagonists
- Development of tricyclic PDE2A-Inhibitors and their use as PET-Radiotracer
Former fields of research
- Synthesis of thieno[2,3-c]pyrazoles having antiulcerative activity
- Synthesis of heterocyclic thioethers with potentially immunomodulating effects
- Synthesis of - linked via a heteroatom - heterobicycles and hetero-carbocycles with inhibitory effect on the cellular uptake of triiodothyronine
- Synthesis and synthetic potential of monocyclic 6-imino-1,3-thiazines
- Synthesis of 2-amino-5-(het)-arylthiophenes and links from cimetidine type as glutamate antagonists
- Synthesis of pyrazolopyrimidines as adenosine A2A antagonists
- Synthesis and conversion reactions of thieno[2,3-d] pyrimidines and thieno [2,3-d]-[1,3]oxazines as inhibitors of the human leukocyte elastase
- Studies on the synthesis of benzylated and monoglucosidic flavonoids as potential inhibitors of protein kinases
- Synthesis and structure-activity optimization of diaryl thiazolo[5,4-c]pyrimidines as adenosine A3A antagonists
- Investigations on subtype-specific GABAA ligands
- Development and evaluation of novel high-affinity fluorescence probes and small molecule inhibitors für sialyltransferases